AccelStab: Accelerated Stability Kinetic Modelling

Estimate the Šesták–Berggren kinetic model (degradation model) from experimental data. A A closed-form (analytic) solution to the degradation model is implemented as a non-linear fit, allowing for the extrapolation of the degradation of a drug product - both in time and temperature. Parametric bootstrap, with kinetic parameters drawn from the multivariate t-distribution, and analytical formulae (the delta method) are available options to calculate the confidence and prediction intervals. The results (modelling, extrapolations and statistical intervals) can be visualised with multiple plots. The examples illustrate the accelerated stability modelling in drugs and vaccines development.

Version: 2.0.1
Depends: R (≥ 4.1.0)
Imports: dplyr, ggplot2, minpack.lm, mvtnorm, stats, scales
Suggests: testthat (≥ 3.0.0), knitr, rmarkdown, lifecycle
Published: 2024-03-26
DOI: 10.32614/CRAN.package.AccelStab
Author: Bernard G Franq [aut, cph], Ben Wells [cre], Alex Ball [ctb]
Maintainer: Ben Wells <benwells at>
License: AGPL (≥ 3)
NeedsCompilation: no
Language: en-GB
Materials: README NEWS
CRAN checks: AccelStab results


Reference manual: AccelStab.pdf


Package source: AccelStab_2.0.1.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): AccelStab_2.0.1.tgz, r-oldrel (arm64): AccelStab_2.0.1.tgz, r-release (x86_64): AccelStab_2.0.1.tgz, r-oldrel (x86_64): AccelStab_2.0.1.tgz
Old sources: AccelStab archive


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