iDOS: Integrated Discovery of Oncogenic Signatures

A method to integrate molecular profiles of cancer patients (gene copy number and mRNA abundance) to identify candidate gain of function alterations. These candidate alterations can be subsequently further tested to discover cancer driver alterations. Briefly, this method tests of genomic correlates of mRNA dysregulation and prioritise those where DNA gains/amplifications are associated with elevated mRNA expression of the same gene. For details see, Haider S et al. (2016) "Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia", Genome Biology, <https://pubmed.ncbi.nlm.nih.gov/27358048/>.

Version: 1.0.1
Depends: R (≥ 3.6.0), VennDiagram (≥ 1.6.5)
Published: 2024-03-11
DOI: NA
Author: Syed Haider [aut, cre], Francesca Buffa [aut]
Maintainer: Syed Haider <Syed.Haider at icr.ac.uk>
License: GPL-2
NeedsCompilation: no
Materials: NEWS
CRAN checks: iDOS results

Documentation:

Reference manual: iDOS.pdf

Downloads:

Package source: iDOS_1.0.1.tar.gz
Windows binaries: r-devel: iDOS_1.0.1.zip, r-release: iDOS_1.0.1.zip, r-oldrel: iDOS_1.0.1.zip
macOS binaries: r-release (arm64): iDOS_1.0.1.tgz, r-oldrel (arm64): iDOS_1.0.1.tgz, r-release (x86_64): iDOS_1.0.1.tgz, r-oldrel (x86_64): iDOS_1.0.1.tgz
Old sources: iDOS archive

Linking:

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